Dr. Driver-Dunckley teaches medical students at the Mayo Medical school and serves as a mentor for students, residents, and junior faculty. She has developed and led several Mayo Clinic CME courses and conferences in Neurology and Movement Disorders. She is the principal investigator or a co-investigator at Mayo Clinic in multiple clinical trials and collaborates with researchers at Arizona State University (ASU) and Banner Sun Health Research Institute.

Her primary research focus is in Parkinson's disease, Progressive Supranuclear Palsy, Essential Tremor, and Restless Legs Syndrome. The research of Erika D. Driver-Dunckley, M.D., focuses on identifying the causes of, and improving the treatments for, Parkinson's disease, atypical parkinsonisms, essential tremor, dystonia, and other movement disorders. These studies involve epigenetics and the pathology of Parkinson's disease and are conducted in collaboration with the Arizona Parkinson's Disease Consortium and the Arizona Study of Aging and Neurodegenerative Disorders.